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Commercial Real Estate for Sale in Upstate SC

Commercial activity in the Upstate follows the interstates. I-85 between Greenville and Spartanburg carries the industrial and distribution demand, with BMW and its supplier network anchoring most of it; retail and office concentrate around the two downtowns and the Highway 9 and Fairview Road corridors.

Commercial runs on different diligence than residential — zoning and permitted use, environmental history, existing leases and their remaining terms, and what a building can actually be converted to. Tell us what you are trying to do and we will scope the search.

Commercial Listings

$249,000
4291008 MLS
Exciting Opportunity in Downtown Columbus – Prime Commercial Acreage at an Incredible Value a fraction of tax value - +/-2.5 Acres! Property is being offered as approximately +/-2.5 acres; the buyer may have the opportunity to purchase additional acreage, less acreage, or the entire parcel!(See other MLS #s) If you’ve been waiting for the right investment opportunity in one of Western North Carolina’s growing corridors, this is one you truly need to walk/run/jog/roll however you need to and see this one to appreciate. LOL With a high traffic count, water/sewer availability per city/seller, and a price point difficult and unheard of to find for commercial acreage in this location, this property offers exceptional upside for investors, developers, business owners, or locals looking to secure land before continued growth pushes values even higher! The possibilities here are truly endless. Whether you envision storage buildings, mixed-use development, affordable or senior housing, office space, a hardware store, recreational facilities, a youth sports complex, skating rink, or something entirely unique, the versatility and location make this tract stand out from the rest. One of the hidden gems of the property is the beautiful flatter area “up top,” offering incredible potential for additional development and usability. Per local grading discussions, access from the main road to the upper section(*this listing - see other listings MLS #s for entire parcel) may be more feasible and affordable than many buyers would expect, creating even more opportunity to maximize the site and future layout possibilities. Conveniently positioned near Advent Health / formerly St. Luke’s Hospital with easy access to I-26 and Highway 74, this location places you right in the middle of the Charlotte, Asheville, and Greenville/Spartanburg growth corridor while still capturing strong local traffic from Columbus, Tryon, Saluda, Landrum, Hendersonville, Forest City, Brevard, and surrounding areas. Future area improvements, including the Rails to Trails expansion and continued YMCA growth nearby, only add to the long-term appeal and traffic exposure. The property also features a creek along the lower backside (***if you purchased the larger piece or all of it together), multiple usable areas, and flexibility for a variety of potential layouts and uses. Buyers are encouraged to explore possible grants, development incentives, lending programs, or investment structures that may be available for their intended project. Cash buyers, investors, and financed opportunities are all welcome! This is the kind of property people look back on and wish they had secured earlier. Call today to schedule your private showing and come walk the land for yourself!

W Mills Street, Columbus

$599,000
4291014 MLS
**Prime Commercial Development Opportunity in Downtown Columbus – Exceptional Value with Outstanding Potential!** Commercial land with this combination of location, infrastructure, visibility, and value is becoming increasingly difficult to find. Schedule your private tour today and come walk the property to fully appreciate the possibilities. Positioned in one of Western North Carolina's fastest-growing corridors, this commercial land opportunity offers outstanding visibility, a strong traffic count, and incredible value at **nearly half of the current tax value**. With city water and sewer available (per seller/utility provider—buyer to verify), this property is well-positioned for a wide variety of commercial or mixed-use development opportunities. Whether you're an investor, developer, business owner, or visionary entrepreneur, this property offers the flexibility to bring your next project to life. Potential uses may include self-storage, office or professional space, retail, mixed-use development, recreational facilities, medical or wellness services, affordable or senior housing (subject to approvals), or other commercial ventures. Buyers are encouraged to verify all intended uses through their due diligence. One of the property's standout features is the large, gently rolling to flatter upper section, providing additional usable acreage with excellent development potential. Preliminary discussions indicate access from the main roadway to the upper portion may be more feasible than many buyers expect, creating opportunities to maximize the site's layout and functionality. Conveniently located near AdventHealth Polk (formerly St. Luke's Hospital), downtown Columbus, and Interstate 26, the property offers easy access to Asheville, Hendersonville, Spartanburg, Greenville, and Charlotte. Its central location places it within an area experiencing continued residential and commercial growth, making it an attractive long-term investment. Additional features include a creek along the rear of the property, multiple usable building areas, and flexibility for a variety of site designs. Buyers should explore available grants, economic development incentives, financing options, or other programs that may support their proposed project. The seller may consider subdividing the right portion of the property (when facing from the roadway). Additional MLS listings are available for related purchase opportunities.

899 W Mills Street, Columbus

$399,000
4292835 MLS
Exciting Opportunity in Downtown Columbus – Prime Commercial Acreage at an Incredible Value a fraction of tax value - +/-4 Acres! Property is being offered as approximately +/-4 acres; the buyer may have the opportunity to purchase additional acreage, less acreage, or the entire parcel!(See other MLS #s) If you’ve been waiting for the right investment opportunity in one of Western North Carolina’s growing corridors, this is one you truly need to walk/run/jog/roll however you need to and see this one to appreciate. LOL With a high traffic count, water/sewer availability per city/seller, and a price point difficult and unheard of to find for commercial acreage in this location, this property offers exceptional upside for investors, developers, business owners, or locals looking to secure land before continued growth pushes values even higher! The possibilities here are truly endless. Whether you envision storage buildings, mixed-use development, affordable or senior housing, office space, a hardware store, recreational facilities, a youth sports complex, skating rink, or something entirely unique, the versatility and location make this tract stand out from the rest. One of the hidden gems of the property is the beautiful flatter area “up top,” offering incredible potential for additional development and usability. Per local grading discussions, access from the main road to the upper section may be more feasible and affordable than many buyers would expect, creating even more opportunity to maximize the site and future layout possibilities. Conveniently positioned near Advent Health / formerly St. Luke’s Hospital with easy access to I-26 and Highway 74, this location places you right in the middle of the Charlotte, Asheville, and Greenville/Spartanburg growth corridor while still capturing strong local traffic from Columbus, Tryon, Saluda, Landrum, Hendersonville, Forest City, Brevard, and surrounding areas. Future area improvements, including the Rails to Trails expansion and continued YMCA growth nearby, only add to the long-term appeal and traffic exposure. The property also features a creek along the backside, multiple usable areas, and flexibility for a variety of potential layouts and uses. Buyers are encouraged to explore possible grants, development incentives, lending programs, or investment structures that may be available for their intended project. Cash buyers, investors, and financed opportunities are all welcome. This is the kind of property people look back on and wish they had secured earlier. Call today to schedule your private showing and come walk the land for yourself!

W Mills Street, Columbus

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The Listings data contained on this website comes from various participants of The Multiple Listing Service of Greenville, SC, Inc. Internet Data Exchange. IDX information is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. The properties displayed may not be all the properties available. All information provided is deemed reliable but is not guaranteed. © 2026 Greater Greenville Association of REALTORS®. All Rights Reserved. Last Updated

“ Based on information submitted to the MLS GRID as of . All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Some IDX listings have been excluded from this website. Properties may or may not be listed by the office/agent presenting the information © 2026 Canopy MLS as distributed by MLS GRID”

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