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Commercial Real Estate for Sale in Upstate SC

Commercial activity in the Upstate follows the interstates. I-85 between Greenville and Spartanburg carries the industrial and distribution demand, with BMW and its supplier network anchoring most of it; retail and office concentrate around the two downtowns and the Highway 9 and Fairview Road corridors.

Commercial runs on different diligence than residential — zoning and permitted use, environmental history, existing leases and their remaining terms, and what a building can actually be converted to. Tell us what you are trying to do and we will scope the search.

Commercial Listings

$950,000
4326757 MLS
Is this the most interesting property available in Asheville? Even without the eclectic furnishings (some of which are available), the unique and versatile layout lends itself to a variety of uses: single-family, multifamily, rental, live/work, artist studio, retail/commercial, or a mix. Zoning is the rare and coveted Neighborhood Business. So many extraordinary touches and endless customizations make it special, showing the high quality and thoughtful design. The studio apartment is being left fully furnished/turnkey and has been a reliable rental at $1800+ per month. Second floor living area has been rented for $2600+ per month. The first floor live/work space is also being prepared for rental which will bring in additional revenue. Amazing location in a friendly neighborhood in between Charlotte St and Merrimon Ave and just a mile to downtown. 3 bedrooms, 4 bathrooms, 3 kitchens, plus a bonus loft at the top! City confirmed that homestay short term rental STR possibility with two of the units with minor modifications if you live in the third. Sellers explored connecting the first and second floors to make it a more traditional two-story home but preferred the current layout so that hasn't been done but is possible according to the sellers and the City. It is well built and well-maintained. Provide proof of funds or preapproval letter with showing request. Check out the 3-D walk-through to get a sense of the layout and efficient design. Sellers are willing to consider owner financing - make an offer!

297 Hillside Street, Asheville

$575,000
4325996 MLS
This is not just a building — it’s a piece of Lowell’s history waiting for its next chapter. Built in 1921, this former bank sits proudly on the corner of E First Street in the heart of Historic Downtown Lowell. Solid brick, full of character, and still home to the original bank vault, it offers the kind of charm and authenticity you simply can’t recreate. Positioned on a corner lot with strong street visibility, this property gives you presence. Whether you’re dreaming of a café, office space, studio, salon, or multi-tenant investment, the layout allows for up to three separate business spaces. There’s also a connecting doorway to 100 Main Street, giving you the flexibility to keep everything unified or operate independently. Upstairs, you’ll find additional square footage (1755sqft) perfect for offices, creative studios, co-working space, or potential future residential use (buyer to verify). The walkable location puts you steps from parks, city hall, local shops, and ongoing downtown development — exactly where foot traffic and community activity are growing. Lowell is a town on the rise, known for its mill-town roots, close-knit community, and revitalized downtown energy. With quick access to I-85 and less than 20 minutes to Charlotte, this location blends small-town character with big-city convenience. Whether you envision a modern café built around the original vault, retail space with historic charm, or a multi-use investment property, 101 E First Street is a rare opportunity to own something truly special in one of Gaston County’s most charming downtowns.

101 E First Street, Lowell

$1,000,000
2 Baths 331315 MLS
Discover an exceptional investment or owner-user opportunity in one of the Upstate’s fastest-growing communities. This 4,144 sq ft former banking branch, prominently positioned at 79 S Main Street, offers unmatched visibility from both Main Street and US-176, placing your business squarely in the path of steady local and commuter traffic. Recently updated in 2020, the interior features modern finishes, open work areas, private offices, conference space, and secure rooms—making the building highly adaptable for a wide range of commercial uses. Whether you envision professional offices, medical or dental practice, insurance agency, real estate brokerage, financial services, retail, or specialty use, this property is built to support your goals. A standout advantage is the existing Bank of America lease for the on-site ATM, providing consistent monthly income—a perfect way to offset ownership costs and strengthen your investment. Positioned in the thriving heart of Downtown Inman, the property benefits from walkable access to local shops, restaurants, and the exciting upcoming Saluda Trail project. Inman continues to experience dynamic residential and commercial growth, making this a strategic location for long-term appreciation and business expansion. Key Highlights: • 4,144± SF former bank branch with 2020 interior updates • Highly versatile layout suitable for office, medical, retail, financial, insurance, real estate, and more • Excellent visibility from Main St and US-176 • ATM lease in place with Bank of America providing monthly income • Located in the center of Downtown Inman, a rapidly growing market • Close to new developments, amenities, and the upcoming Saluda Trail All information provided regarding this property, including but not limited to square footage, site details, permitted uses, restrictive covenants, easements, leases, rights-of-way, and any other property conditions, is deemed reliable but not guaranteed. Prospective purchasers are strongly encouraged to conduct their own independent due diligence, including verification of all documents, restrictions, zoning, measurements, and any other information material to their decision to purchase. Neither the Seller/Owner, the Listing Brokerage, nor the Listing Agent makes any representation or warranties, expressed or implied, regarding the accuracy or completeness of the information provided. All parties shall hold the Seller, Listing Brokerage, and Listing Agent harmless from any liability arising from the use or interpretation of the information contained herein. All offers and sales are subject to the terms of any and all existing covenants, leases, easements, rights-of-way, and applicable South Carolina real estate laws and regulations.

Inman

$435,000
20294723 MLS
609 Fair Street offers a plethora of amenities! This property currently houses a spacious 2-bedroom home, complete with a fully functional automotive garage in the back. The home boasts all gas appliances, including an instant water heater, stove, gas pack heat, and even a gas dryer. Spanning over 1290 square feet, the home features luxurious LVP flooring throughout. The kitchen has undergone a recent renovation, complete with granite countertops. The primary bedroom boasts a generous walk-in closet and a full bathroom equipped with a dual-head shower. Located in the thriving City of Anderson, this property presents an ideal opportunity for aspiring business owners. It could easily accommodate the current garage operation behind the home, providing a convenient space for automotive repairs and maintenance. Alternatively, it could serve as an attractive investment property, offering rental potential with both the home and the garage. The garage itself is a substantial 3000 square feet under roof, featuring a 14-foot tall roll-up door. Inside, there’s a dedicated bathroom, 210 square feet of office space, and 600 square feet of overhead storage. The building’s impressive height of 18 feet ensures ample room for two car lifts and even more if needed. One lift is rated to carry up to 9,000 pounds, while the other can handle up to 12,000 pounds. The shop is renowned in the area, having been in operation for years. It comes equipped with a used oil heater, air compressor, and two Brake lays, all of which will remain with the shop, subject to an acceptable offer.

609 Fair Street, Anderson

$435,000
1 Baths 1574828 MLS
609 Fair Street offers a plethora of amenities! This property currently houses a spacious 2-bedroom home, complete with a fully functional automotive garage in the back. The home boasts all gas appliances, including an instant water heater, stove, gas pack heat, and even a gas dryer. Spanning over 1290 square feet, the home features luxurious LVP flooring throughout. The kitchen has undergone a recent renovation, complete with granite countertops. The primary bedroom boasts a generous walk-in closet and a full bathroom equipped with a dual-head shower. Located in the thriving City of Anderson, this property presents an ideal opportunity for aspiring business owners. It could easily accommodate the current garage operation behind the home, providing a convenient space for automotive repairs and maintenance. Alternatively, it could serve as an attractive investment property, offering rental potential with both the home and the garage. The garage itself is a substantial 3000 square feet under roof, featuring a 14-foot tall roll-up door. Inside, there’s a dedicated bathroom, 210 square feet of office space, and 600 square feet of overhead storage. The building’s impressive height of 18 feet ensures ample room for two car lifts and even more if needed. One lift is rated to carry up to 9,000 pounds, while the other can handle up to 12,000 pounds. The shop is renowned in the area, having been in operation for years. It comes equipped with a used oil heater, air compressor, and two Brake lays, all of which will remain with the shop, subject to an acceptable offer.

609 Fair Street, Anderson

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The Listings data contained on this website comes from various participants of The Multiple Listing Service of Greenville, SC, Inc. Internet Data Exchange. IDX information is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. The properties displayed may not be all the properties available. All information provided is deemed reliable but is not guaranteed. © 2026 Greater Greenville Association of REALTORS®. All Rights Reserved. Last Updated

“ Based on information submitted to the MLS GRID as of . All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Some IDX listings have been excluded from this website. Properties may or may not be listed by the office/agent presenting the information © 2026 Canopy MLS as distributed by MLS GRID”

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