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Commercial Real Estate for Sale in Upstate SC

Commercial activity in the Upstate follows the interstates. I-85 between Greenville and Spartanburg carries the industrial and distribution demand, with BMW and its supplier network anchoring most of it; retail and office concentrate around the two downtowns and the Highway 9 and Fairview Road corridors.

Commercial runs on different diligence than residential — zoning and permitted use, environmental history, existing leases and their remaining terms, and what a building can actually be converted to. Tell us what you are trying to do and we will scope the search.

Commercial Listings

$1,395,000
1588836 MLS
Welcome to 906 Augusta Street in Greenville, a rare and highly versatile property offering residential, office, and short-term rental potential in one of the city’s most established and rapidly evolving corridors. Zoned MX2 in a desirable Opportunity Zone. Positioned just minutes from downtown, this expansive ±4,000 sq ft property delivers flexibility that is nearly impossible to find in today’s market. Whether envisioned as a primary residence, professional office space, income-producing short-term rental, or a mixed-use investment, the layout and site design support a wide range of uses. A few of the property’s most significant advantages are the brand new roof and its dedicated 12-car parking lot, an exceptional amenity for this area and a major differentiator for both commercial and STR uses. With four separate exterior access doors, the building naturally lends itself to multi-tenant configurations, private suites, or segmented functional use. Potential for office users, medical/spa concepts, creative studios, or short-term rental operators seeking operational flexibility. Inside, the structure offers generous square footage with adaptable rooms, multiple entry points, and a layout that can be configured for private offices, guest suites, or open collaborative space depending on use. Natural light and scale throughout provide a strong foundation for customization. The location enhances both lifestyle and business appeal. Situated along Augusta Street, the property offers quick access to the vibrant energy of downtown Greenville, including Main Street, and nearby destinations such as Falls Park on the Reedy, award-winning dining, boutique shopping, and cultural attractions. The property also offers convenient access to Prisma Health and major thoroughfares, making commuting effortless. This connectivity makes it equally attractive for residential living, client-facing businesses, or high-demand rental guests. Property is under 24 hour surveillance.

906 Augusta Street, Greenville

$789,000
20300187 MLS
No Restrictions ! No HOA ! Sewer available, sewer man hole located in front of the property, can tap on at Wells Highway across the highway at buyers expense. 2.36 acres of un-restricted acreage that backs up to Clemson University land and has 572.52 ft of Clemson Blvd road frontage. The property was previously leased at $ 7000 per month to KX Clemson Fraternity that installed a Golf Par Three 110 yard putting green at the rear right corner near the shade tress before reaching the flowing creek. The fenced in property with gated entrance has RV Boat storage with power and water, several RV hookup sites.There is a detached Garage, Work Shop with Storage storage that leads up the concrete drive to the 2400 SF white brick building with a 2 car attached garage with an additional 784 SF of unfinished basement space. The freshly painted interior has hardwood floors on the main level that features a kitchen with breakfast bar, dining area, great room, 3 bedrooms, two full bathrooms, laundry room with sink that leads to the garage. The basement features another bedroom, full bath, full kitchen, recreational room, and unfinished storage. Ideally located midway to Clemson from Seneca for a Commercial Business at a traffic light intersection. Close to Clemson University, shopping, dining, medical, recreational, Lake Keowee and Lake Hartwell, close to everything. Great location for Retail, Office, Medical, Apartments, Nursery. Buyers to verify everything of importance. No Zoning ! Live there and run a business ! Enough land to build several cottages to rent out !

10695 Clemson Boulevard, Seneca

$1,200,000
4330874 MLS
If you’ve been looking for a place where you can live and work without sacrificing the neighborhood, this is one of those rare finds. A place to run your business up front and retreat to an industrial-style loft in the back, complete with approximately 20-foot ceilings that give the space volume, light, and the distinct urban character you don’t often come across in this city. Set in Chantilly, one of Charlotte’s most established and sought-after in-town neighborhoods, this property offers a natural fit for a business that values visibility, accessibility, and a strong surrounding potential customer base. It’s the kind of location where people already live, walk, and engage—making it easy for a business to feel like part of the community from day one. What really sets it apart is the flexibility. In addition to the commercial space, the property includes a separate living area that lends itself well to an industrial loft-style residence. Whether you choose to live on-site, create a private retreat, host a visiting professional, or generate additional income, the setup gives you options that are increasingly hard to find in this area. Just as important is how easily the property fits into everyday life. You can start your morning with a short walk for coffee, open your doors to clients who appreciate the setting as much as the service, and wind down in the evening with dinner or a drink nearby. It’s a rhythm that feels natural here—easy, connected, and distinctly Charlotte. The space works well for a variety of uses, from boutique retail and design studios to wellness concepts or a professional office looking for something more personal and neighborhood-driven. It’s not just about having a place to operate—it’s about creating something that feels rooted and intentional. And with Plaza Midwood just minutes away, you’re close to some of the city’s best restaurants, coffee shops, and everyday conveniences, adding another layer of energy and walkability to the experience. For someone looking to bring together business, lifestyle, and location in a meaningful way, this is a unique and compelling opportunity.

2644 Shenandoah Avenue, Charlotte

$1,475,000
4 Baths 4370646 MLS
Fully renovated mixed-use property on the Gateway to Asheville’s River Arts District and Biltmore Village. Located at the corner of Amboy Road and State Street, directly across from Carrier Park and the French Broad River Greenway, this site offers exceptional visibility 12,000+ cars daily—and quick access to I-26 (less than ½ mile). Amboy Road links Biltmore Village, the River Arts District, and West Asheville’s thriving neighborhoods, forming one of the city’s most desirable recreational and commercial corridors. Main Level Features: • Inviting bar space with covered patio and serving window NEW exterior seating the ( Bench Fence) • Central courtyard separating bar from café/kitchen area • Rear sections include 16’ ceilings, three glass garage doors, raised floor area Exterior features include open patio, boulder circled fire pit and creekside yard, Plenty of parking • Excellent natural light and flexible layout for events or dining Upper Level Features: • Commissary kitchen with 3-bay sink, hand sink, dry storage, cooler areas, staff bath, Chef’s office, Additional Highlights: • Zoning: River - Mixed-use / commercial • New Certificate of Completion • Ample onsite parking with easy access • NNN lease | Subdividable | Flexible terms available This property is ideal for a bar, café, food service venture, or creative mixed-use concept. With minimal build-out remaining, it’s ready for immediate occupancy—allowing operators to focus on their vision rather than construction. Built to last, steeped in local history, and poised for its next chapter—this property offers the perfect stage for Asheville’s next great concept.

219 Amboy Road, Asheville

$699,500
1 Baths 4368999 MLS
7.86% Cap! Rare, turnkey self-storage and industrial income property now available in the growing Etowah/Flat Rock corridor. 130 Oakland Hill Drive offers an investor or owner-user a stabilized self-storage operation (40 units), a contractor garage, open-air RV / boat / trailer storage, and a main industrial building with two bays, with immediate vacancy on one side - ready for owner occupancy or lease-up on day one. The current operator runs a car detailing business out of the main building and will vacate upon sale, giving the new owner a clean slate for their own use or the opportunity to capture market-rate lease income. Pro forma NOI of $55,000 is well-supported by three years of trailing financials. 2025 reflects non-recurring capital expenditures with add-backs available to the underwriting-minded buyer. Full financials attached. Additional upside exists for a buyer who leases the main building or pushes rents on the storage inventory. Current ownership has invested meaningfully in the business and physical infrastructure - new automated gate system, redesigned website, and streamlined operations. The asset weathered Helene with no flooding, and is well-positioned for a new owner to step in and operate efficiently from day one. A full unit schedule is attached separately. Etowah sits at the heart of Henderson County's commercial growth corridor, with easy access to Hendersonville, Brevard, and Asheville. Strong demand for self-storage and contractor/outdoor storage is driven by residential growth, the trades, and outdoor recreation culture. DO NOT DISTURB Tenants. All showings must be scheduled through List Agent(s). Proof of Funds or other Credibility Package required to schedule showing.

130 Oakland Hill Drive, Etowah

$299,500
2 Baths 4369037 MLS
Rare opportunity to acquire a fully built-out medical office condominium in the heart of Asheville's healthcare corridor... steps from Mission Hospital and minutes from downtown. Unit 5H2 at Doctors Park offers an investor or owner-operator a turnkey income stream with immediate upside through occupancy of one currently vacant office. The unit features five private offices - three with plumbing, suitable for exam or treatment use - along with a dedicated waiting room, reception area, break room, two restrooms, and storage. Four of the five offices are currently leased to established behavioral health, counseling, and wellness practitioners, generating $2,185 per month in gross revenue. The vacant fifth office is ready for immediate occupancy, offering an owner-operator the ability to plant their own practice within an existing, well-established medical community. Doctors Park is one of Asheville's most recognized professional medical addresses, home to a dense ecosystem of healthcare providers across multiple disciplines. The property's proximity to Mission Hospital - HCA Healthcare's flagship regional facility - makes it a natural choice for practitioners seeking referral proximity and patient convenience. Downtown Asheville, with its amenities and strong regional draw, is less than two miles away. The POA Fee covers utilities, common area maintenance, and parking, simplifying operating overhead for both the current owner and future tenants. At $612.95 per month, this fee is among the most competitive in the building. Whether you are an investor seeking a stabilized, income-producing asset in a supply-constrained medical submarket, or a healthcare provider looking to own your office while generating rental income from neighboring suites, this unit offers a compelling entry point. DO NOT DISTURB Tenants. All showings must be scheduled through List Agent(s). Proof of Funds or other Credibility Package required to schedule showing.

5 Doctors Park Unit #H2, Asheville

$599,900
4 Baths 4369653 MLS
The Fox-Ingold House, known by most locals as the "Hospitality House," is now available! Come discover the perfect location for your next Bed & Breakfast, professional office, or charity headquarters! Located in the Claremont Historic District of downtown Hickory, this 1897 Queen Anne offers 5 bedrooms/offices, 4 bathrooms and period detailing inside and out. Details include 9 fireplaces, each with unique mantels, hand carved stairway posts, stained glass windows, original hardwood flooring, original wainscoting, built-ins, the list goes on! The main level offers a large central foyer opening onto two front parlors, a dining room with original built-in china cabinet and wainscoting, main-level bedroom with en-suite bonus room, kitchen, laundry, and mud room. Wind your way upstairs via a hand-carved staircase made of heart pine, leading to another large landing with a stained glass exit to the centrally located upper level porch. Upstairs, four generously sized bedrooms all offer fireplaces and share a hall bathroom. Outside, a wonderful wrap-around porch welcomes guests year-round and features classic 19th century detailing that can only be found on historic properties. Located withing walking distance to downtown Hickory shopping and dining, LRU sporting events, and local schools and churches. Seller is a historic preservation organization requiring protective covenants attached to the deed at sale protecting the historic integrity of the structure, materials and site. Most changes proposed to the property will require seller’s review and approval. Modernization of the kitchen and baths are generally permitted. Roof on home will need to be replaced in near future. Seller is unsure of AC functionability. In the past, parking has been allowed in hospital parking lot behind home, details are being negotiated for total number of spots.

121 5th Ne Avenue, Hickory

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