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Commercial Real Estate for Sale in Upstate SC

Commercial activity in the Upstate follows the interstates. I-85 between Greenville and Spartanburg carries the industrial and distribution demand, with BMW and its supplier network anchoring most of it; retail and office concentrate around the two downtowns and the Highway 9 and Fairview Road corridors.

Commercial runs on different diligence than residential — zoning and permitted use, environmental history, existing leases and their remaining terms, and what a building can actually be converted to. Tell us what you are trying to do and we will scope the search.

Commercial Listings

$775,000
3 Baths 4393257 MLS
Beautiful Historic Turn-Key Airbnb Home & Business Just 10 Minutes from Downtown Asheville – Residential & Commercial Zoning! An exceptional opportunity to own a successful turn-key Airbnb, charming historic home, and commercially zoned property all in one. Originally built in 1914 and situated on nearly an acre, this 3-bedroom, 3-bathroom property seamlessly blends timeless character with modern updates and endless potential. A welcoming wraparound front porch sets the tone, offering the perfect place to relax and enjoy the peaceful surroundings. Inside, the spacious living room serves as the heart of the home, creating a warm and inviting gathering space for guests and residents alike. The formal dining room is filled with natural light and provides an ideal setting for entertaining. Historic charm can be found throughout the home, while recent updates—including the kitchen, bathrooms, and all replacement windows—provide modern comfort and convenience. Spacious bedrooms offer comfortable accommodations, and the upstairs loft provides flexible space for a home office, reading nook, lounge area, or additional guest accommodations. Currently operating as a successful Airbnb, this property offers immediate income-producing potential. Most furnishings may be included with the sale (see private remarks for exclusions), allowing for a truly turn-key transition for investors or owner-operators. Adding even more value, the property is zoned for both residential and commercial use, creating a wide range of possibilities including continued short-term rental operations, office space, retail, boutique lodging, or a live-work setup. The nearly one-acre lot may also offer subdivision potential, providing additional flexibility and future development opportunities. Enjoy the tranquility of a spacious property while remaining less than 10 minutes from the shops, restaurants, breweries, and entertainment of Downtown Asheville. Whether you're seeking a residence, business opportunity, investment property, or all three, this unique offering delivers exceptional versatility and potential. Also listed as a residential property - MLS#4393254

615 Rose Hill Road, Asheville

$4,950,000
1594421 MLS
DEVELOPERS DREAM! Welcome to Rocky River Plantation, formerly known as “Valley View,” a Southern masterpiece along the Rocky River. Step back in time and immerse yourself in the elegance of the early 20th century with this stunning Greek Revival estate, located at 2000 East River Street, Anderson, SC. Built in 1913 by Mr. Seybt, this historic home is a true architectural gem and a rare opportunity to own a piece of Southern history. Nestled on 62.34 acres of picturesque land, Rocky River Plantation seamlessly combines timeless grandeur with modern potential. The 4,000-square-foot home is a commanding structure featuring ten spacious rooms, two room-sized halls, a basement, and a permanent staircase leading to two attic rooms. The first floor boasts soaring 11-foot ceilings, while the second floor stands at an impressive 10 feet. The craftsmanship is impeccable, with two-inch slash pine floors intricately laid in patterns and architectural details such as front-facing columns and additional columns within the grand entrance hall. A large wrap-around porch further enhances the home’s charm, offering the perfect space to enjoy serene views and Southern hospitality. Designed by architects Joe Casey and Charles W. Fant, Sr., this home has been cherished by notable owners, including former U.S. Congressman John C. Taylor and his family. Beyond the house itself, the expansive grounds offer over 2,000 feet of frontage along the scenic Rocky River, providing breathtaking natural beauty and abundant recreational opportunities. Additionally, the property boasts 2,600 feet of road frontage along US Highway 178, offering unparalleled access and visibility. Located in the heart of Anderson, South Carolina, Rocky River Plantation is centrally positioned at the intersection of US Highway 178 and US Highway 29. The property is unzoned and unrestricted, with all major utilities in place, including sewer, high-KVH power, a 10-inch natural gas line, fiber, and a 12-inch water line. These features make the estate a prime redevelopment site for multi-family residential, commercial, or industrial projects. Rocky River Plantation stands as a testament to enduring beauty and refined Southern living. Whether you dream of restoring this historic treasure to its original glory or envisioning a modern redevelopment that harnesses its potential, this estate offers a truly unique canvas for your vision.

2000 E River Street, Anderson

$1,950,000
1594425 MLS
Endless investment potential on one of Anderson's most iconic corners! Nestled in one of Anderson’s most prominent and well-trafficked locations, this multi-building, multi-tenant portfolio property offers an unparalleled opportunity for business owners and investors alike. Occupying nearly half of one of the city’s most iconic blocks, this property is a cornerstone of Anderson’s bustling commercial hub. Its strategic location at the intersection of E Greenville Street and Main Street ensures maximum visibility and accessibility, making it an ideal destination for retail, professional services, or dining establishments. Spanning 1.21 acres with over 14,000 square feet of versatile space, the property features multiple buildings designed to accommodate a range of commercial needs. Positioned at the corner of E Calhoun and McDuffie Streets, the site also enjoys frontage along E Greenville Street, with red-light access on three sides to ensure seamless traffic flow for patrons and clients. The property’s layout offers flexibility, allowing tenants to customize the spaces to suit their specific requirements, whether they are a retail vendor, restaurateur, or professional office provider. The visibility and accessibility of this property are unmatched. Its location within the heart of Anderson places it amidst thriving businesses, providing a steady stream of potential customers. The property’s position on key city streets ensures consistent exposure to both pedestrian and vehicle traffic, making it a highly desirable site for a range of ventures. Whether you’re looking to establish a flagship retail store, expand a professional office portfolio, or create a dining destination in one of South Carolina’s fastest-growing cities, this property offers the space, location, and flexibility needed to bring your vision to life. With its prime location and multi-tenant potential, this commercial listing is a rare opportunity to secure a presence in the heart of Anderson’s vibrant economic landscape. Don’t miss your chance to be part of this thriving community.

110 E Greenville Street, Anderson

$990,000
3 Baths 4382929 MLS
Exceptional opportunity to acquire one of Western North Carolina's most distinctive and historically significant properties. Located in the highly desirable Fairview community just minutes from Asheville, this unique offering combines authentic Appalachian heritage, exceptional craftmanship, flexible use potential, and highly sought-after mountain lifestyle setting. The centerpiece of the property is a remarkable 2600+ square foot log residence constructed from three original hand-hewn log cabins dating to the 1800's obtained by the builders from neighboring Madison County and Leicester community. The cabin sits on the original site of one of the first schools in the Fairview community. Carefully preserved and thoughtfully integrated into a comfortable modern home the structure showcases the character, craftsmanship, and architectural details rarely found in today's marketplace. Original exterior doors from the 1800's, multiple fireplaces, exposed wood elements, and historic materials create an atmosphere that cannot be replicated through new construction. Positioned on approximately 1.85 acres, the property offers a private and inviting setting while maintaining convenient access to Asheville, the Blue Ridge Parkway, area hiking trails, dining, Lake Lure, shopping, arts, entertainment, and the region's thriving tourism industry. The location provides an attractive balance of accessibility and mountain tranquility, making it suitable for a variety of commercial, hospitality, and investment-oriented subject to buyer verification of zoning, permitting and regulatory requirements. In addition to the main residence, the property includes a detached two-car garage with upper-level storage space and a separate cabin with power. This additional structure offers flexibility for use as an artist's studio, writer's retreat, office, workshop, guest accommodation, creative workspace, or support facility for a hospitality-oriented operation. The property's historic significance and unique architectural character create opportunities that extend beyond traditional ownership. Potential uses may include a boutique inn, destination lodging property, vacation rental enterprise, executive retreat, wellness retreat, creative arts retreat, educational venue, corporate gathering space, special event destination, or other tourism-related enterprise. The combination of authentic historic construction, mountain ambiance, and proximity to Asheville creates a compelling experience for guests, visitors and clients seeking accommodations and venues with genuine character and regional authenticity. Western North Carolina continues to attract visitors, retirees, second-home owners, entrepreneurs, and investors drawn by the area's naturals beauty, outdoor recreation, cultural amenities, and strong tourism properties possessing authentic historic provenance are increasingly rare, particularly those offering flexibility for income-producing or commercial applications. Opportunities of this nature seldom become available. This property is zoned OU (open use) by Buncombe County. Recently added heat/air to the 670 square foot small cabin adjacent.

75 Old Gap Creek Road, Fairview

$12,000,000
4392229 MLS
Once-in-a-Lifetime Estate in Union Mills! This extraordinary property offers unlimited possibilities with 65 gently rolling acres, an 8,950 sq. ft. lodge, a one-bedroom Gate House, and 6 brand-new log cabin rentals, plus additional development opportunities throughout the property. The lodge is perfectly designed across two levels. The main floor features 4,952 sq. ft. with a massive open great room highlighted by a stunning stone gas fireplace, a sunroom with a hot tub, 4 spacious bedrooms, a TV room, a double kitchen, a bar area, 4 large bathrooms, and a laundry room. The second floor offers 3,998 sq. ft. with 7 large bedrooms, 3 bathrooms, a theater room, a game room, and an additional laundry room. The Gate House is a beautifully finished one-bedroom rental complete with its own private hot tub. The six new log cabins are thoughtfully positioned for privacy, each featuring a covered deck and private hot tub. This property has hosted many weddings and events with a large guest capacity, making it a premier destination for celebrations, retreats, and gatherings. In addition to the existing improvements, there are 8 additional cabin or RV sites ready to go, and the property has a conceptual layout plan showing the potential for up to 88 total RV sites. Whether you’re looking for a luxury private estate, a thriving hospitality business, an RV resort, an equestrian property, a wedding venue, or a family retreat, this property can bring your vision to life. Adding to its uniqueness, the far corner of the property adjoins a Conserving Carolina protected area of approximately 1,500 acres, providing additional privacy and natural beauty. Conveniently located with easy access to I-40, it’s just 24 miles to Tryon International Equestrian Center, 46 miles to Asheville, and 84 miles to Charlotte. This is truly a one-of-a-kind Western North Carolina mountain estate. Schedule your private tour today and experience everything this incredible property has to offer.

1470 Thermal City Road, Union Mills

$889,000
4391205 MLS
Position your business for success with this flexible warehouse located directly on Spartanburg Highway—offering outstanding visibility and ease of access. This property is designed to support a wide range of industrial operations, from manufacturing to logistics and service-based trades or an auto/workshop shop. Inside, you’ll find multiple private offices —ideal for administrative and management functions. The facility includes three restrooms and a convenient mezzanine level for extra storage or operational flexibility. The heart of the property features expansive shop space, including a 2,200 SF bay (45’ x 49’) and an additional 775 SF bay (25’ x 31’), both with 18'/16’ clear height, providing plenty of room for machinery, workstations, or inventory. Four 12’H x 10’W roll-up doors offer smooth access for equipment and vehicle movement. Behind the building, the large fenced lot offers secondary access from Charming Pointe Lane, with access wrapping around the building that could support fleet or material storage, deliveries, and easy maneuvering of large vehicles. Whether you’re expanding, relocating, or launching a new operation, this property offers the space, functionality, and location your industrial business needs. Located in the heart of East Flat Rock, this property offers easy access to I-26, and is situated on the corridor between Asheville and Greenville, SC, just south of Hendersonville, NC.

2997 Spartanburg Highway, Asheville

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“ Based on information submitted to the MLS GRID as of . All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Some IDX listings have been excluded from this website. Properties may or may not be listed by the office/agent presenting the information © 2026 Canopy MLS as distributed by MLS GRID”

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