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Commercial Real Estate for Sale in Upstate SC

Commercial activity in the Upstate follows the interstates. I-85 between Greenville and Spartanburg carries the industrial and distribution demand, with BMW and its supplier network anchoring most of it; retail and office concentrate around the two downtowns and the Highway 9 and Fairview Road corridors.

Commercial runs on different diligence than residential — zoning and permitted use, environmental history, existing leases and their remaining terms, and what a building can actually be converted to. Tell us what you are trying to do and we will scope the search.

Commercial Listings

Spartanburg
$535,000
3 Baths ⋅ 342438 MLS
TWO PROPERTIES. ONE INCREDIBLE OPPORTUNITY! Welcome to 1586 Skylyn Dr, a versatile property featuring an updated all brick ranch sitting on 0.59 acres, a brand new 600 sq ft ADU, excellent visibility and direct access to the Mary Black Rail Trail. Located along one of Spartanburg's established healthcare and professional corridors, the property is positioned between Spartanburg Medical Center, Drayton Mills Elementary, and Spartanburg Day School, with Converse University just minutes away. This unique setup offers exceptional flexibility for commercial use, multigenerational living or investment purposes. The main ranch offers over 1,866 sq ft of single-level living with a charming front porch, beautiful hardwood floors, cozy gas fireplace, natural gas furnace and an oversized family room that could function as a conference room, meeting space, executive office, or waiting area. The home offers a spacious primary suite with two closets and a ceramic tile walk-in shower and two additional rooms with a full bath. A covered two-car carport with additional storage provides convenient parking and functionality. The detached ADU adds incredible versatility and value. Featuring three bedrooms, 1.5 baths, a full kitchen with custom quartz countertops and large windows with tons of natural light. There is one full bedroom and full bath downstairs with a laundry room and a unique spiral staircase leading to two additional bedrooms upstairs. The ADU offers exceptional flexibility for guests, family, workspace or additional income potential. A Jack-and-Jill-style half bath serves the upstairs bedrooms, while a new mini-split HVAC system provides comfort year round. New plumbing, electrical and roof complete the space, along with a private rear deck offering direct access to the Mary Black Rail Trail. With excellent visibility and immediate proximity to Spartanburg Medical Center, Gibbs Cancer Center, Spartanburg Day School and surrounding medical, dental and professional offices. This property is ideally positioned for a medical practice, dental office, chiropractic or therapy practice, wellness business, or other approved commercial use. The existing layout offers multiple rooms that can easily transition into offices, treatment rooms, conference areas, reception space or private work areas. For residential buyers, the property offers an uncommon opportunity for multigenerational living, extended family, guests, older children or private workspace. Investors can benefit from the separate ADU and the property's highly visible location and flexible layout. The spacious lot provides outdoor space, parking potential and room to explore future improvements or development opportunities. Direct access to the Mary Black Rail Trail adds a unique lifestyle benefit, while the location is minutes from Converse University, Spartanburg High, and tons of amenities on East Main, including Publix, the Fresh Market, NCG Cinemas, Lowe's, and Home Depot. Opportunities combining a renovated brick ranch, detached ADU, covered parking, excellent visibility, healthcare proximity, educational destinations and direct trail access are hard to find. Whether your vision is residential, commercial, multigenerational, owner-user or investment purposes, 1586 Skylyn offers the space and flexibility to make it happen!

Spartanburg

3840 Robert Riding  Road, Shelby
$125,000
1 Baths ⋅ 4430061 MLS
Built in the 1930s and originally used as part of a dairy farm, this approximately 5,997-square-foot building has been preserved through generations and has continued to serve as a place of craftsmanship and woodworking. For the current owners, furniture craftsmanship has been a family tradition passed down through generations, giving this property a history that is still very much present today. Situated on approximately 0.76 acres and located less than 500 feet from Highway 74, the property is within the Highway 74 corridor zoning area. Its location provides convenient access to the greater Western North Carolina and Upstate South Carolina region, with Asheville approximately 80 miles away and Charlotte, Spartanburg, Greenville, and the Tryon area all within reach. The building sits on a slab and offers a large, open workshop area with plenty of room for woodworking, furniture production, fabrication, storage, or other potential uses. The property features gas heat, a bathroom, and well water, with no central air. No septic record was located on file. With nearly 6,000 square feet, convenient access to Highway 74, and proximity to several of the region’s major cities and commercial areas, this property offers a unique opportunity for someone looking for a substantial workshop or commercial space with genuine character. This building has been more than just a workshop, it has been part of a family’s story for generations. Its next use may look different, but the history and character that have been preserved here are something you simply can’t recreate.

3840 Robert Riding Road, Shelby

109 N Main  Avenue, Newton
$559,900
4427574 MLS
ATTENTION ENTREPRENEURS AND INVESTORS! What could you create with 7,430 square feet in Downtown Newton, NC? This large, two-story commercial building offers prominent Main Avenue frontage, excellent visibility, and convenient access to Hickory, Charlotte, and I-40. Located in a growing community, Newton continues efforts to attract visitors, businesses, events, and activity to its historic center. This location puts your business or investment in the middle of that ongoing revitalization and provides an opportunity to become part of the area's continued growth. Currently configured for a successful martial arts/fitness operation with bathrooms, showers, office space, and large open areas, the existing setup creates an opportunity for an easy transition to a kids' gym or activity center, fitness facility, dance studio, or similar use. The size and layout open the door to bigger ideas: business or professional offices, medical office, medical spa, specialty retail, restaurant or entertainment concepts, or picture a restaurant with rooftop dining or a unique rooftop bar. Perhaps a large upper-level primary residence, or multiple townhomes, with a business below. The right buyer could create a unique mixed-use destination unlike anything else in the area. And there is room to grow. Approximately 1,120 square feet of unfinished space is located on the upper level and could potentially be incorporated into the second floor by adding a floor over an existing open area at the rear of the building. If completed, the property could offer approximately 8,550 square feet of total space, including roughly 4,500 square feet upstairs and 4,280 square feet downstairs, subject to verification and applicable building requirements. This is more than a commercial building — it's a blank canvas with the size, visibility, and layout to bring a big idea to life. Come walk the space, look at the possibilities, and see what you can create. Restrictions are subject to City of Newton Planning and Zoning. Please do not disturb tenant. Showings by appointment only.

109 N Main Avenue, Newton

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The Listings data contained on this website comes from various participants of The Multiple Listing Service of Greenville, SC, Inc. Internet Data Exchange. IDX information is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. The properties displayed may not be all the properties available. All information provided is deemed reliable but is not guaranteed. © 2026 Greater Greenville Association of REALTORS®. All Rights Reserved. Last Updated

“ Based on information submitted to the MLS GRID as of . All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Some IDX listings have been excluded from this website. Properties may or may not be listed by the office/agent presenting the information © 2026 Canopy MLS as distributed by MLS GRID”

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